(233e) Computational Fluid Dynamics (CFD) Guided Scale up of Cell Culture Bioreactors from Bench to Pilot to Commercial Scale
- Conference: AIChE Annual Meeting
- Year: 2016
- Proceeding: 2016 AIChE Annual Meeting
- Group: Pharmaceutical Discovery, Development and Manufacturing Forum
Monday, November 14, 2016 - 3:15pm-5:45pm
This study used single phase simulations to predict power input and mixing time of production bioreactors at different scales. Impeller power numbers generated by CFD were compared across sites and assessed against historical vendor values to align cross-site scale up parameters. Approaches to applying CFD to large scale cell culture bioreactors will be discussed.