(233ag) Characterization of Compaction Behaviour of Powders in Solid-Dosage Manufacturing Using Finite Element Analysis
- Conference: AIChE Annual Meeting
- Year: 2016
- Proceeding: 2016 AIChE Annual Meeting
- Group: Pharmaceutical Discovery, Development and Manufacturing Forum
Monday, November 14, 2016 - 3:15pm-5:45pm
In this study, the mechanical properties of a range of pharmaceutical formulations were approximated using the modified Drucker-Prager Cap (DPC) plasticity model and applied for FEA. The DPC model parameters were varied depending on the local relative density using an external subroutine. Additionally, the effect of wall friction on the mechanical behaviour of different formulation compacts during compaction is explored. This numerically predicted density distribution is compared with experimental measurements. The verification results are important for establishing a predictive capability of this model. The results from this study contribute to a better understanding of the impact of powder properties and process settings on the tabletting process and final properties of the produced tablet.