Population Balance Modeling for Particle Formation Processes: Nucleation, Aggregation and Breakage Kernels

Ramachandran, R., Rutgers University
Rajniak, P., Research Center Pharmaceutical Engineering

Contributions are sought in the general area of population balance modeling and control of particle formation processes. Topics of interest include, but are not limited to: (1) the identification of nucleation kinetics and kernels for coalescence, aggregration, agglomeration, and breakage; (2) numerical algorithms for efficiently solving the associated population balance equations with complex particle dynamics; (3) model reduction methods and their application to optimization and feedback control; (4) experimental design methods, to focus experimental efforts on identifying kernels and nucleation kinetics; (5) nonlinear control methods designed to optimize distributions; and (6) mathematical methods for analyzing the sensitivities of the distributions to model uncertainties and disturbances. All application areas involving population balance modeling are of interest including nanoparticle formation, solids flows, granulation processes, solution crystallization, spray drying, precipitation, and emulsion and suspension polymerization.



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