(159f) Spherical Agglomeration of API: Screening Protocol, Process Design and Scale-Up
AIChE Annual Meeting
2013
2013 AIChE Annual Meeting
Particle Technology Forum
Agglomeration and Granulation Processes
Tuesday, November 5, 2013 - 4:45pm to 5:03pm
Spherical agglomeration is a technique to grow agglomerates from already formed particles using a L-L-S system where one liquid phase preferentially wets the surface of the solid phase.
Spherical agglomeration can be used to produce granular API with improved bulk density and flow properties as well as improved filterability. A generic screening protocol is presented to allow for rapid screening of spherical agglomeration conditions for water insoluble compounds. For Compound A, process design at 100 mL scale will be discussed. The scale up of spherical agglomeration for Compound A to 1 L and 50 L scale will then be presented and discussed.
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