Crystallization Process Development I - Techniques and Tools

Simon, L. L., ETH Zurich

Crystallization is an important unit operation in the chemical industry, especially in the isolation and purification of pharmaceuticals and other fine chemicals. However, developing a crystallization process is a challenging problem in itself. The mixture to be separated often involves multiple components, and it is crucial that the solids are consistently obtained in the right polymorphic forms, compounds, adducts, or solvates. The particles need to be in the right size distribution in order to avoid problems such as difficult filtration or high residual impurity content. This session focuses on methods, techniques, or tools that can lead to faster and better development of crystallization processes.



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