(672b) Introducing Contcarsim, a Benchmark Simulator for Design and Control of Continuous Integrated Filtration-Drying of Crystallization Slurries
AIChE Annual Meeting
Thursday, November 17, 2022 - 3:51pm to 4:12pm
In this presentation, we demonstrate advanced operation design, monitoring and control applications in pharmaceutical development and manufacturing through ContCarsim, a novel simulator for continuous integrated filtration-drying of crystallization slurries. ContCarSim, publicly released in the MATLAB environment, aims at promoting the adoption of advanced operation design, process monitoring and control by the pharmaceutical community within the quality-by-design and quality-by-control initiatives (ICH, 2009; Su et al., 2017), by making available a digital environment where the user can easily test and benchmark control strategies, or generate data for process analytics studies.
ContCarSim allows the user to simulate the operation of a novel carousel technology for continuous integrated filtration-drying, in normal operating conditions or under a set of different disturbance scenarios. Furthermore, the user-friendly structure of ContCarSim allows the implementation on the simulator of user-conceived control strategies, which may include advanced elements such as, for instance, model predictive control and state estimation. We demonstrate the use of ContCarSim through the implementation of a three-layer control system, featuring an end-point controller based on state estimation, which terminates filtration and drying cycles when the target product quality has been achieved. The proposed control system also includes a real time optimization routine, for maximizing the throughput of dry crystals obtained from the unit operation.
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