(367b) A Note on Selectivity of Co-Solvent for Drug Production Process Using Ternary Infinite Dilution Activity Coefficient –Etodolac + Water + Co-Solvent System –

The selection of co-solvent discussed in drug production process is one of important themes. The calculation of the solid-liquid equilibria for the drug + water + co-solvent (liquid and solid) is made using activity coefficient models [1, 2].

This article deals with the calculation of solubilization power and stability constant [3, 4] using ternary infinite-dilution activity coefficients. The selection of solvents is considered for etodolac + water + co-solvents (cyclodextrin derivatives, 1,4-dioxane, methanol) system.

References

[1] H. Matsuda, K. Kaburagi, K. Kurihara, K. Tochigi, and K. Tomono, Fluid Phase Equilibria 290 (2010) 153-157.

[2] K. Tochigi, H. Matsuda and K. Kurihara, Proceedings of AIChE 2021 annual meeting (2021)

[3] H. Matsuda, S. Matsumoto, K. Kaburagi, K. Kurihara, K. Tochigi, and K. Tomono, Fluid Phase Equilibria 302 (2011) 115-122.

[4] Y. Naito, H. Matsuda, K. Shimomura, K. Kurihara, K. Tochigi and K. Tomono, Fluid Phase Equilibria, 357 (2013) 43-49.