(336c) Automated Continuous Crystallization Platform | AIChE

(336c) Automated Continuous Crystallization Platform


Nandiwale, K. - Presenter, Massachusetts Institute of Technology
Girard, K., Pfizer, Inc
Pritchard, R., Contingent Worker, Eurofins Scientific for Pfizer Worldwide Research and Development
Nowak, C., Pfizer Inc
Zhao, Z., The University of Oklahoma
Guinness, S. M., Pfizer Inc.
Continuous flow crystallization is an attractive mode of operation, due to its ability to generate consistent product quality while requiring a smaller footprint and lower production costs than its batch counterpart. We present the development of an automated continuous crystallization platform at Pfizer as a part of the Flexible API Supply Technology (FAST) initiative. This lab-scale continuous crystallization consists of a three-stage continuous stirred tank reactor (CSTR) system. LabVIEWâ„¢ software was designed and written in-house for the purpose of automated analysis and to control various hardware including a flow sonicator, feed pumps, and temperature controllers. We demonstrate the integration of a variety of in-line process analytical technology (PAT) tools, including Focused Beam Reflectance Measurement (FBRM), EasyViewerâ„¢, Blaze, and Infrared (IR) spectroscopy within this environment. By integrating equipment, PAT, and control software into a single, automated platform, enhanced real-time process understanding, identification of optimal conditions, and acceleration of development timelines are realized.