(315g) Design and Function of Peptide-Based Materials
AIChE Annual Meeting
Tuesday, November 15, 2022 - 2:18pm to 2:54pm
We addressed this need with a new molecular discovery tool. Rather than attempt a brute-force approach, we instead identify a new strategy for discovering and studying intermolecular interactions; âco-assembly of oppositely charged peptide" (CoOP), a framework that `encourages' peptide assembly by mixing two oppositely charged hexapeptides.1This results in a reasonable expansive design space of fibrillar assemblyâs within that space leading to substantially increased efficiency in the exploration. The one-dimensional assemblies that form through this unique CoOP approach are well suited for study via a set of reliable quantitative tools. We showed that the peptides that are designed with CoOP strategy have wide application areas. The peptides that self-assemble into the fibrillar structures created hydrogels with different mechanical properties, based on their aggregation kinetics and affinity. Additionally, we showed the use of these peptides as vaccine adjuvants.2 We showed that the CoOP approach represents a unique, simple, and elegant framework that can be used to identify the structure-property relations of self-assembling peptide-based materials.
 Hamsici, S., White, A. D. & Acar, H. Science Advances (2022)