(679d) A Mechanistic Approach to Predicting Oxygen Mass Transfer in Bioreactors.
AIChE Annual Meeting
Monday, November 15, 2021 - 4:45pm to 5:10pm
In this presentation, we propose a modeling capability in which hydrodynamics of a bioreactor along with its capability in transferring oxygen to the working fluid is assessed and validated against a set of published experimental data in literature. Specifically, we employ first principle mechanistic modeling to model oxygen mass transfer in a widely used lab-scale bioreactor (AMBR 15). For the first time, to the best of our knowledge, we show how this application allows the prediction of oxygen mass transfer to the fluid from both the open surface and sparger. This methodology is based on sound first principles and thus is not bioreactor specific, in other words, it can be applied across a wide range of scales and bioreactors.