(644f) Formulation, Stability, and Scalability of Fast-Releasing Lumefantrine Nanoparticles for the Treatment of Malaria
- Conference: AIChE Annual Meeting
- Year: 2020
- Proceeding: 2020 Virtual AIChE Annual Meeting
- Group: Pharmaceutical Discovery, Development and Manufacturing Forum
- Time: Thursday, November 19, 2020 - 9:15am-9:30am
We compare lyophilized and spray dried lumefantrine NP powders and confirm that using spray drying as our solidification method does not compromise the dissolution kinetics and can therefore be used as a cost effective and scalable drying method. The dissolution kinetics for the spray dried NP powders remain constant under fasted and fed conditions for over a month in accelerated stability testing conditions (50°C, 75% RH, open vial). Via Powder X-ray diffraction, differential scanning calorimetry, and solid-state nuclear magnetic resonance, we confirm that the lumefantrine in the core of the nanoparticle is amorphous. The combination of FNP and spray-drying offers a low-cost, scalable, and continuous nanofabrication platform to produce amorphous nanoparticles in a solid dosage form.