(334bq) Development of Process Models and Control Strategies to Support the Continuous Manufacturing of Pharmaceuticals

Throughout my PhD I have worked on the advancement of modeling and control for the continuous manufacturing of pharmaceuticals. I have been the primary contributor on three main projects and a secondary contributor on a few others.

The first of these projects focused on the development of a virtual plant for the manufacturing of a small molecule active pharmaceutical ingredient. The plant was used to inform process design and process control for the manufacturing system.

The second of these projects focused on the development of a model for the production of recombinant proteins in the host, Pichia pastoris. The model was validated with existing literature and used to understand long-term process stability and explored methods to analyze and increase this stability.

The third of these projects involves on construction of a testbed for the continuous manufacturing of monoclonal antibodies. The system is heavily instrumented so that diverse datasets can be generated for process model and control strategy development. For this, I have worked on data integration, control strategy development, and process modeling for the system.

Outside of these projects, I have a working knowledge of viral vector (specifically recombinant adeno-associated viruses) and vaccine manufacturing. I am looking for a job to leverage my experience in process modeling and control for the advancement of pharmaceutical manufacturing processes.