Process Design & Development

A Strategy for Excellence in Process Development

Process Development
Vaibhav V. Kelkar, Lionel O'Young
Here is how to integrate overall process development activities and identify practices that facilitate commercial process development.

Size Letdown Lines for Pressure Surges

Fluids and Solids Handling
Gianni  Anci
A high-pressure gas flow in a letdown circuit can cause damage to piping and equipment. Here is how to design a system to avoid damage should a pressurized gas flow occur GianniAnci-

Optimize Power Consumption in Aerobic Fermenters

Reactions and Separations
Gregory T. Benz
By performing the necessary pilot work, and rigorously calculating the full-scale performance instead of using simple rules-of-thumb, significant energy savings can be achieved in fermenters.

Reduce Risk When Sourcing Abroad

Fluids and Solids Handling
Gregory T. Benz, Ling Du
Purchasing lower-cost process equipment from vendors in developing nations can be an attractive proposition in times of economic austerity. When sourcing outside local channels, keep the points discussed here in mind to avoid costly problems that go...

Squeeze More Out of Complex Columns

Reactions and Separations
Piyush Shah
These distillation setups can cut capital and operating costs by up to 30%, and increase separation efficiency. Here is a straightforward method for evaluation.

Selecting Agitator Seals for Bioprocessing Applications

Fluids and Solids Handling
Gregory T. Benz, William Ho Liam Teng
Issues such as sterility, isolation and contamination must be considered when choosing seals for use in biotech and pharmaceutical processes. This overview describes common types of seals and offers guidance on selecting the appropriate seal for...

The Flange Factor in Gasket Selection

Fluids and Solids Handling
Dave Burgess, John Crandall
Gaskets should be chosen based on service conditions, as well as the type of flanges to be sealed. These principles will help to guide the selection.

Fermentation Goes Large-Scale

Special Section
Aristos Aristidou , J. J. Hahn , Pim van Hoek , Alex Patist
Designing an economically competitive and environmentally sustainable fermentation route means considering the downstream separations needed to capture the final product during the initial process design.

Ensure Proper Design and Operation of Multi-Pass Trays

Reactions and Separations
Mark Pilling
To function properly at optimum capacity and efficiency, multi-pass trays must be designed so that the liquid and vapor flows are properly balanced. This article provides guidance on how to achieve that.

Minimize Scale-Up Risk

SBE Special Section
J. Brad Cort, Thomas Pschorn, Bertil Stromberg
Proven commercial-scale equipment already exists for many operations involved in producing biofuels from lignocellulosic feedstocks.

Keys to Bioreactor Selection

Reactions and Separations
John A. Williams
A few basic types of bioreactor designs are used to produce a wide range of products, from antibiotics to foods to fuels. Here's how to pick the best options for your application.

Succeed at Catalyst Scale-Up

Reactions and Separations
Richard Allen, William H. Beever, Jeff Braden, Donald R. Engelbert, J. Todd Osbourne, Uday T. Turaga, Ben Wagner
Follow these principles to reduce the time required for scale-up and commercialization to improve the resource effectiveness of the effort.

Principles and Case Studies of Simultaneous Design

September, 2011
There are many comprehensive design books, but none of them provide a significant number of detailed economic design examples of typically complex industrial processes. Most of the current design books cover a wide variety of topics associated with process design. In addition to discussing...

Pump Wisdom: Problem Solving for Operators and Specialists

April, 2011
An accessible guide to the main reasons pumps fail—and what can be done about it Workhorses in many different industries, including the oil industry, water industry, chemical industry, food industry, and pharmaceutical industry to name a few, pumps are a vital contributor to maintaining and...

Teach Yourself the Basics of Aspen Plus

January, 2011
Aspen Plus is on of the most popular process simulation software programs used industrially and academically. Though the software is available at many corporations and universities, there are no textbooks which are dedicated to teaching the step-by-step use of the software. This book is designed to...

Reactive Distillation Design and Control

October, 2008
After an overview of the fundamentals, limitations, and scope of reactive distillation, this book uses rigorous models for steady-state design and dynamic analysis of different types of reactive distillation columns and quantitatively compares the economics of reactive distillation columns with...

Chemical Reactor Design, Optimization, and Scaleup, 2nd Edition

August, 2008
Chemical Reactor Design, Optimization, and Scaleup is the authoritative sourcebook on chemical reactors. This new Second Edition consolidates the latest information on current optimization and scaleup methodologies, numerical methods, and biochemical and polymer reactions. It provides the...

Chemical Reactor Design and Control

August, 2007
Chemical Reactor Design and Control uses process simulators like Matlab, Aspen Plus, and Aspen Dynamics to study the design of chemical reactors and their dynamic control. There are numerous books that focus on steady-state reactor design. There are no books that consider practical control systems...

Distillation Design and Control Using Aspen Simulation

April, 2006
As the world continues to seek new sources of energy, the distillation process remains one of the most important separation methods in the chemical, petroleum, and energy industries. And as new renewable sources of energy and chemical feedstocks become more universally utilized, the issues of...


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