Process Design & Development

Piloting Bioreactors for Agitation Scale-Up

February
2008
Reactions and Separations
Gregory T. Benz
This article offers guidance on how to design appropriate experiments to measure scalable data for agitation in both aerobic and anaerobic bioreactors.

Optimizing Crystallizer Scaleup

June
2003
Fluids and Solids Handling
Wayne Genck
Explore how mixing parameters impact the crystallization process and recommend ways to improve the likelihood of successful scaleup. The concepts of nucleation and growth, types of mixing, design considerations, agitator parameters and scaleup...

Best Practices for Pilot-Plant Piping

April
2014
Fluids and Solids Handling
Richard Palluzi
Pilot-plant piping is subject to more-frequent modification than typical process plant piping, and must be able to accommodate a range of media, temperatures, and pressures during its lifetime. Use this guide to determine which piping, tubing, and fittings are optimal for your pilot plant application.

Increase Powder Flow via Gas Injection

July
2006
Fluids and Solids Handling
John W. Carson, Herman Purutyan, Thomas G. Troxel
Fluidization and air-assisted discharge are two ways to optimize fine-solids handling. However, the choice of technology is as important as designing and operating the system properly.

Selecting Laboratory Reactors

August
2007
Reactions and Separations
Francesco Picciotti, Marcello Picciotti
This article outlines some of the considerations involved in selecting and specifying a reactor system for research and development applications.

Reduce Piloting Time and Cost

July
2011
Process Development
David A. Berg, Michael T. Cleary
Pilot-scale experimentation is essential to establish a sound foundation for a new chemical processing unit. These best practices can reduce the time and cost involved in process development.

Designing Polymerization Reaction Systems

February
2016
Reactions and Separations
Shrikant Dhodapkar, Pradeep Jain, Carlos Villa
Important considerations in polymerization reactor design include heat removal, kinetics, and process dynamics, as well as polymer properties and product quality.

Put More Punch Into Catalytic Reactors

March
2003
Reactions and Separations
Ed Fontes, Olof Hernell, Phil Byrne
Using equation-based modeling to design these reactors can optimize their efficiency and throughput.

Evaluating the Economics of Desalination

December
2002
Heat Transfer
Hisham M. Ettouney, Hisham T. El-Dessouky, Peter J. Gowin, Ron S. Faibish
This article presents an in-depth analysis of thermal and membrane desalination economics and outlines a simple procedure for calculating the unit product cost for various desalination processes.

Understand Pilot-Plant Design Specifications

May
2016
Plant Design
Adam Whalley, P.Eng.,
Although pilot- and commercial-scale plants may appear similar, they must be designed with different objectives in mind. Find out how the design criteria for pilot and commercial plants differ, and why commercial specifications should not be applied to pilot plants.

Engineering Global Biological Solutions

Conference Presentation
AIChE Annual Meeting
November 17, 2014
The past decades have seen biopharmaceuticals begin to dominate the drug development pathway and already we can see potent biologics bringing...

Impact of Recycling Light Olefins to the FCC

Conference Presentation
AIChE Annual Meeting
November 17, 2014
Recycling light olefin product streams back to a fluid catalytic cracking (FCC) unit has potential applications in US refineries due to the growing...

Gas Trial for FLNG Nearshore Commissioning

Conference Presentation
AIChE Spring Meeting and Global Congress on Process Safety
April 2, 2014
Gas trial is the important process to evaluate Cargo System Performance for FLNG Project. Several methods are now being considered and we will...

Maximizing CO2 Uptake in Concrete Blocks Carbonation

Conference Presentation
AIChE Annual Meeting
November 8, 2013
Maximizing CO2 uptake in concrete blocks carbonationYixin Shao1* , Yaodong Jia1 , Zhen He2 and Liang Hu31Department of Civil Engineering , McGill...

Complex Fitness Diagrams and Downstream Processing

Conference Presentation
AIChE Annual Meeting
November 5, 2013
Focus here is development of production scale processes and specifically with modifying optimized laboratory processes that are unsuitable for large-...

Risk Assessment Challenges 20:20

Conference Presentation
Southwest Process Technology Conference
October 3, 2013
A wide variety of hazard identification and risk assessment techniques are available. All techniques require knowledge in the fundamentals of the...

Management Discipline: Defining a Process Safety Strategy

Conference Presentation
AIChE Spring Meeting and Global Congress on Process Safety
April 30, 2013
Management Discipline: Defining a Process Safety Strategy Jerry J. Forest - Global Process Safety Manager, Celanese jerry.forest@celanese.com...

The Design and Revamp of Cooling Water Networks

Conference Presentation
AIChE Spring Meeting and Global Congress on Process Safety
April 30, 2013
Cooling Water Networks G.T.Polley , M.Picon Nunez & E.Tamakloe Dept. of Chemical Engineering, University of Guanajuato, Mexico In Reality:...

Current Myths about LNG

Conference Presentation
AIChE Spring Meeting and Global Congress on Process Safety
April 29, 2013
Since the startup of the first baseload LNG plant (Camel) in 1964, there have been several generations of LNG plant designs. Each generation can be...

Optimal Design of Transient Microreactor Experiments

Conference Presentation
AIChE Annual Meeting
October 30, 2012
Development of synthetic routes for active pharmaceutical ingredient (API) synthesis is increasingly performed using microreactors, because their use...

A Novel QbD Tool for Statistical Data Analysis

Conference Presentation
AIChE Annual Meeting
October 30, 2012
One of cornerstones of Quality by Design (QbD) is Design of Experiments (DoE). However, in addition to DoE, ICH Q8 (R2) recommends an enhanced...

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