On the Evolutionary Metabolic Hypothesis of Cancer (EMHC)

This study introduces a hypothesis which is based on the Warburg Hypothesis [M1] and also lends further support to the metabolic theory of cancer put forth by Prof. Thomas N. Seyfried. As nearly all cancer cells have defective mitochondria they are unable to produce energy from oxidative phosphorylation. Instead, they generate ATP primarily from fermentation of glucose in the cytosol. Understanding the significance of this landmark hypothesis offers oncologists and cancer biologists insight into evolutionary aspects of this disease and new directions for research and treatment strategies based on cancer cell vulnerabilities.