Controlled Drug Delivery System

Authors: 
Shi, W., Virginia Tech
Yuan, X., Virginia Tech
Essandoh, D., Virginia Tech
The general goal of this project is to develop a controlled drug delivery system for cancer nanomedicine, and evaluate its feasibility. Controlled drug delivery focuses on the method of giving drugs continuously for prolonged time periods in a controlled fashion [1]. It has the advantages of improved efficiency, reduced toxicity, maintenance of drug levels within desired range, and fewer administrations [2]. This delivery system is built upon an optical fiber, on which coatings of PLA, PLGA, and rhodamine B (a tracer dye used in place of the medicine) are applied. After rhodamine B is allowed to release in PBS solution, data is analyzed through HPLC to obtain the relationship between percent of release and time. As the result, the dye is released fast at first, slowly down over time, and it can be kept until 48 hours. Therefore, its continuous and long-range release achieves the idea of controlled drug delivery; the future in vivo studies using the same delivery system can be expected to follow a similar trend. Amount of medicine released at certain times within a biological body can be easily predicted.


Reference

[1] D. L. Wise, Handbook of Pharmaceutical Controlled Release Technology: CRC Press, 2000.

[2] A. G. a. I. Singhvi, "Concepts of Sustained Release Dosage Forms," International Journal of Applied Pharmaceutical and Biological Research, 2016.