Elementary Mode Analysis of the Effect of Redox Balance over H2 Production in Rhodopseudomonas Palustris

Saldivar-García, A., Instituto Politécnico Nacional
Gonzalez-Garcia, R. A., The University of Queensland
Salgado Manjarrez, E., Unidad Profesional Interdisciplinaria de Biotecnología, Instituto Politecnico Nacional
García-Peña, E. I., Instituto Politécnico Nacional
The adoptive transfer of T cells expressing chimeric antigen receptors (CARs) has demonstrated clinical efficacy in the treatment of advanced cancers, with anti-CD19 CAR-T cells achieving up to 90% complete remission among patients with relapsed B-cell malignancies. However, challenges such as antigen escape and immunosuppression limit the long-term efficacy of adoptive T-cell therapy. Here, I will discuss the development of next-generation T cells that can target multiple cancer antigens and resist immunosuppression, thereby increasing the robustness of therapeutic T cells against tumor defense mechanisms. This presentation will highlight the potential of synthetic biology in generating novel mammalian cell systems with multifunctional outputs for therapeutic applications.