Therapeutic Strategies Via CRISPR-Cas: New Approaches and New Challenges  | AIChE

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Therapeutic Strategies Via CRISPR-Cas: New Approaches and New Challenges 

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Mali, P. - Presenter, University of California San Diego
The recent advent of RNA-guided effectors derived from clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated (Cas) systems have dramatically transformed our ability to engineer the genomes of diverse organisms. As unique factors capable of co-localizing RNA, DNA, and protein, tools and techniques based on these are paving the way for unprecedented control over cellular organization, regulation, and behavior. Here I will describe some of our ongoing efforts towards engineering this system for enabling therapeutic applications.