Application of Cationic Polymers for In Vivo Antibacterial Applications

In the recent year, the appearance of multiple resistances of the antimicrobial agent toward the different types of pathogenic bacteria is the most prominent threat to the global public health. The invention of antibiotic to the medical field has great impact on human mortality and morbidity. However, the multi drug resistance (MDR) effect of the pathogenic bacterial towards commonly used antibiotics has impeded the treatment of bacterial infections.
In the recent few decades, the Antimicrobial polymers (AMPos) have been widely used as a promising antimicrobial alternative to combat the infectious disease caused by MDR bacterial. Hence, unlike traditional antibiotics, AMPos interact with the bacterial membrane through non-specific electrostatic interaction. This electrostatic mode of interaction offers the AMPos to progressively interact with the bacterial with a less likely hood of bacterial resistance. We have developed numerous cationic polymer solutions that are bactericidal in vivo with a murine wound model.
We have also developed a series of chitosan-based low molecular weight chitosan derivatives. It can kill MRSA in excisional wound model. The mechanism of kill and the solution properties of these low molecular weight chitosan derivatives shall be presented. antibacterial hydrogel based on AMPos that is intrinsically antibacterial and non-leachable.