Fast and Furious: Cell-Free Biomanufacturing Approaches
We propose that these limitations can be overcome using cell-free biomanufacturing. Case studies will be presented for a rapid response to a radiological incident, where large quantities of GCSF will need to be therapeutically administered. Currently, GCSF is stored in the Strategic National Stockpile, but faces constant expiration and replenishment requirements. In contrast, we show how a cell-free approach can be used to overcome these limitations.
Other biologics/vaccine candidates, scale-up possibilities and regulatory barriers will be discussed.