In this work, the integration of dry granulation into a continuous tableting line is investigated. Specifically, the Process Analytical Technology (PAT) tools required for inline and at-line monitoring of the tableting line, and the semi-mechanistic models for the roller compactor and the tablet press are discussed. While the Kawakita model is used for the tablet press, the roller compaction process model is consisting of an integration of material balance and actuator dynamics from Hsu et. al (2010) with the modified Johansonâs model presented by Liu & Wassgren (2016). The PAT tools, mechanistic equations, and automation system are integrated for measurement validation and data accuracy using data reconciliation in a structured ISA-95 network using DeltaV. The experimental data is presented from the operation of the continuous dry granulation line-based pilot plant at Purdue University.