(54aw) Milling and Grindability Assessment of Pharmaceutical Materials

Authors: 
Bonakdar, T., University of Leeds
Ghadiri, M., University of Leeds
Hassanpour, A., University of Leeds
Roberts, K. J., Institute of Particle Science and Engineering
Milling is one of the most important unit operations in the pharmaceutical industries. Most of the Active Pharmaceutical Ingredients (APIs) and excipients are produced by crystallisation, and grown to a sufficiently large particle size suitable for isolation and drying. Therefore most of the materials have to be milled to desirable particle sizes. Milling is influenced by a combined effect of milling dynamics (input power, mill geometry, etc) and material properties. Considerable research has been carried out on analysing the particle behaviour in various mills. Nevertheless, the prediction of the milling rate and milled product properties (e.g. product size distribution) is still very challenging.

In this work, the milling behaviour of several pharmaceutical materials in the PicoPlex mill (pin mill unit of the Picoline, Hosokawa Alpine) has been studied. A combination of experiments and Distinct Element Method (DEM) simulations is used to explore the dynamic behaviours of the materials in the mill. The results are then used to validate a novel approach of grindability assessment of pharmaceutical materials using the Scirocco disperser of the Malvern Mastersizer 2000 (Bonakdar et al. 2016). Based on this method the ease of grindability of the materials in the mill can be predicted.

Bonakdar, T., Ali, M., Dogbe, S., Ghadiri, M., and Tinke, A. (2016). A method for grindability testing using the scirocco disperser. International Journal of Pharmaceutics, 501: 65-74