(54aw) Milling and Grindability Assessment of Pharmaceutical Materials
World Congress on Particle Technology
Tuesday, April 24, 2018 - 11:45am to 1:15pm
In this work, the milling behaviour of several pharmaceutical materials in the PicoPlex mill (pin mill unit of the Picoline, Hosokawa Alpine) has been studied. A combination of experiments and Distinct Element Method (DEM) simulations is used to explore the dynamic behaviours of the materials in the mill. The results are then used to validate a novel approach of grindability assessment of pharmaceutical materials using the Scirocco disperser of the Malvern Mastersizer 2000 (Bonakdar et al. 2016). Based on this method the ease of grindability of the materials in the mill can be predicted.
Bonakdar, T., Ali, M., Dogbe, S., Ghadiri, M., and Tinke, A. (2016). A method for grindability testing using the scirocco disperser. International Journal of Pharmaceutics, 501: 65-74