(23a) Heterogeneous Liposome Assemblies: When Soft Meets Hard (Invited)
In our work we have designed liposome-based entities that consist from one or more liposomes as compartments and can contain also iron oxide nanoparticles (MgNPs) for remote control of the aggregate and/or silica nanoparticles to improve the loading capacity. We have tested several different approaches of forming the liposomal aggregates, including use of the alginate microcapsules as liposomes â MgNPs vehicle, charged liposome aggregation due to high ionic strength of the buffer, using DNA amphiphiles as anchors between liposomes, and using polyelectrolytes such as poly-L-lysine as a glue for charged liposomes and MgNPs. This last approach was studied extensively and resulting aggregates, stabilized using the MgNPs, were tested for their ability to follow the magnetic field and to perform remotely triggered release. We have also tested the method of increasing the loading capacity of individual liposomes using porous silica nanoparticles (due to their good sorption properties). Such approach can significantly increase the loading capacity of liposomes and influence their response to external stimulus.