(16b) Novel Technologies to Improve the Bioavailability, Content Uniformity and Manufacturing of Pharmaceuticals
- Conference: World Congress on Particle Technology
- Year: 2018
- Proceeding: 8th World Congress on Particle Technology
- Group: Applications of Particle Technology for Pharmaceuticals
- Time: Monday, April 23, 2018 - 2:00pm-2:30pm
Fluidized bed impregnation can be summarized as the combination of three distinct processes taking place simultaneously. These include fluidization of the porous carrier, spraying API solution within the bed, which penetrates the excipient due to capillary forces, and drying of the porous particles causing the API to be deposited within. In this talk, we will present results showing that this process can deliver powder with high blend uniformity and tablets/capsules with high content uniformity. In addition, we show that the final API loading is not limited by its solubility in the organic solvent. Our results also show that fluidized bed impregnation does not depend on the nature of the API but rather on the nature of the excipient used. The product is an excipient impregnated with API that has flow properties that depend on the excipient and not on the physical properties of the API. In addition, we show that the product that is produced can significantly increase the dissolution kinetics of poorly soluble APIs. Implementing fluidized bed impregnation in drug manufacturing could allow for significant cost savings due to elimination of several unit operations.