(107c) Investigating the Removal of Staphylococcus Aureus from Substrates By Modulating of Protein-Substrate Interactions (Invited) | AIChE

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(107c) Investigating the Removal of Staphylococcus Aureus from Substrates By Modulating of Protein-Substrate Interactions (Invited)

Authors 

Balasubramanian, V. - Presenter, University of Florida
Nandakumar, V., University of Florida
Moudgil, B. M., Centre for Particulate and Surfactant Systems
Nosocomial pathogens can be transmitted through person to person, environment or contaminated water and food, infected individuals, contaminated healthcare personnel's skin or contact via shared items and surfaces. Staphylococcus aureus is the second leading cause of nosocomial bacteremia and also one of the most antibiotic resistance bacteria. S.aureus often interacts with the host via secreted and surface-anchored proteins, and is determined to be more strongly adhered to the host surface than E.coli.

The increase of multidrug-resistant strains has created an urgent need for the development of alternative approaches that focus on removal rather than killing of bacteria. To investigate the removal based approach, catatonically modified silica particles have shown promise in our laboratory. It has been hypothesized that the modified particle interaction with the bacteria must be stronger than bacteria- host surface interactions. In this study, a combination of silica particles and amino acids including arginine and tryptophan are expected to modulate the interactions between bacteria and surface. This knowledge will be helpful in developing additives for the suppression of protein-substrate interactions, thereby enhancing the removal of S.aureus and further reducing the transmission of nosocomial infections.

Topics 

Protein Engineering

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