(39a) Data-Driven, Model-Based Approaches to the Scale-up, Transfer and Alignment of Processes
AIChE Spring Meeting and Global Congress on Process Safety
Monday, April 23, 2018 - 3:30pm to 3:55pm
Although the models are built using data from the processes at the different scales using empirical multivariate latent variable methods, theoretical calculations involving engineering calculations on mixing characteristics, energy balances, etc. are readily included.
Examples given will include: (i) the scale-up of a roller compaction process from a laboratory compactor to a full-scale compactor in a pharmaceutical company; (ii) the scale-up of a batch pulp digester process; (iii) the transfer of production between batch reactors in a specialty chemical process; and (iv) the alignment of batch reactors in a biopharmaceutical plant to achieve similar yields and quality.