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Chronic Recurrent Multifocal Osteomyelitis (CRMO) is an autoinflammatory bone disorder that causes patients to exhibit chronically active or recurrent sterile bone lesions at multiple sites. The chronic multifocal osteomyelitis (cmo) mouse carries a mutation in the Pstpip2 gene and develops IL-1b mediated sterile bone disorder reminiscent of human CRMO. On the other hand, mutation in the LPIN2 gene that encodes for , a vital molecule in lipid metabolism, is known to cause an autoinflammatory disease called Majeed syndrome which is characterized by CRMO, dyserythropoietic anemia, and may have neutrophilic skin inflammation. Previous reports have shown that cholesterol levels in the cells regulate IL1b production by the Lpin2 deficient immune cells. To investigate the cholesterol synthesis in the bone marrow cells from cmo and Lpin2 deficient mice, expression of genes involved in cholesterol biosynthesis was performed using quantitative PCR method. We found that the expression of several cholesterol biosynthesis pathway genes is attenuated in cmo mice-derived cells, suggesting that difference in the levels of cholesterol in the cells might be involved in the susceptibility/resistance from the cmo disease.