(693b) Automated Platform for Experimental Execution and Model Regression of Volumetric Mass Transfer Coefficient and Vessel Characterization
- Conference: AIChE Annual Meeting
- Year: 2019
- Proceeding: 2019 AIChE Annual Meeting
- Group: Pharmaceutical Discovery, Development and Manufacturing Forum
- Time: Thursday, November 14, 2019 - 12:51pm-1:12pm
As an alternative to traditional pressurization/depressurization tests to determine kla, we have been refining experimental methods which leverage the dynamics of oxygen dissolution following a change in the equilibrium concentration of oxygen. These methods are often tedious to execute and require careful experimental planning and data capture and as a result, we sought to develop an automated platform for experimental execution, data stream integration and kla regression. Additionally, this automated platform was applied to characterize oxygen mass transfer in reactors of various geometries ranging in scale from 10 mL to 100 L to demonstrate the value of this platform for the scale up of aerobic oxidations.