(675e) Controlled Microfluidic Synthesis of Polymeric Nanoparticles for Drug Delivery
The coaxial jet mixer was used to synthesize poly(ethylene glycol)-b-poly(lactide) (PEG-b-PLA) NPs in various solvents. The resulting NP size was controlled between 40 and 140 nm by tuning flow conditions and solvent. Process scale-up lead to NP production rates of up to 175 mg min-1 under stable operation. A model drug, Indomethacin, was encapsulated within PEG-b-PLA NPs at drug loadings that were comparable to standard batch nanoprecipitation but with a smaller diameter and more narrow polydispersity. A unique advantage of the coaxial jet mixer was the ability to rapidly screen formulation conditions, which enabled new insights into the effect of solvent on nanoparticle formation.
Overall, this presentation will present a versatile and robust device for NP synthesis while providing fundamental insights on engineering efficient nanoformulations.
1 Kamaly, N., Xiao, Z., et al. Chem. Soc. Rev. 41, 2971â3010, (2012)
2 Shi, J. et al. Nat. Rev. Cancer 17, 20â37, (2017)
3 Hickey, J. W. et al. J. Control. Release 219, 535â547, (2015)
4 Lim, J.-M. et al. ACS Nano 8, 6056â6065, (2014)
5 Karnik, R., Gu, F. et al. Nano Lett. 8, 2906â2912, (2008)