(499b) Automated Nanomole-Scale Platform for Rapid Screening and Optimization of Electroorganic Synthesis
- Conference: AIChE Annual Meeting
- Year: 2019
- Proceeding: 2019 AIChE Annual Meeting
- Group: Pharmaceutical Discovery, Development and Manufacturing Forum
- Time: Wednesday, November 13, 2019 - 12:55pm-1:20pm
Here, we demonstrate a fully automated droplet-based screening platform to enable rapid examination of the electrochemical reactions with nanomole amount of reagents, which can potentially facilitate the mechanistic understanding of the electrochemical systems. This platform achieved 10-fold increase in screening throughput compared to traditional batch screening approach. Electrochemical radical cross-coupling reactions are examined on this system. Additionally, we demonstrate the optimal electrochemical reaction condition obtained from the screening platform can be directly applied to the large-scale electrosynthesis to quickly access the desired substrate.