(42b) Study on the Non-Isothermal Dehydration Kinetics of Cefminox Sodium

Drugs containing crystal water account for a large proportion in solid crystalline drugs. The presence of crystal water will affect the internal energy, entropy and enthalpy of the crystal, further affecting its stability, solubility and biological drug efficiency. Therefore, it is of great significance for practical production to study the mechanism of drug crystal dehydration process and establish its dehydration kinetic model Thermal analysis technology is a kind of technology to determine the relationship between physical properties and temperature under the premise of controlling the heating rate. In the field of pharmaceutical research, this technology is mainly applied to the detection of drug polymorphism and the characterization of thermal stability, etc., and its analysis results can often be used as an indicator of process condition evaluation in chemical production. There are seven crystal water in the molecule of Cefminox sodium. The amount of crystal water may change with the change of environment, which may affect the quality of the product. Therefore, in this chapter, the non-isothermal dehydration kinetics model of cefminox sodium was systematically established through the thermal analysis of cefminox sodium, and the kinetic factors of its dehydration process A, E, f(α), were obtained, which provided support for the subsequent process research.