(340f) Evaporative Heat Transfer Model for QbD of Agitated Filter Bed Drying
AIChE Annual Meeting
2019 AIChE Annual Meeting
Pharmaceutical Discovery, Development and Manufacturing Forum
Innovations in Particle Engineering: From Amorphous Solid Dispersions to New Processing
Tuesday, November 12, 2019 - 2:15pm to 2:36pm
Scale-up/tech-transfer of drying process is quite challenging as different AFDs have different surfaces that could transfer heat that ends up impacting effective heat transfer coefficients across the bed as we scale the process. Understanding of bed temperature and residual solvent across the filter cake is critical for reliable and robust scale-up of AFD drying protocol.
In this work, we present results from a novel 3D heat-transfer model that allows us to understand the temperature evolution across the filter cake considering the equipment variability at scale. We also present experimental techniques that can be employed to extract relevant model parameters. In the end, we would provide the decision tree to guide efficient design and reliable scale-up of agitated filter drying.
All authors are AbbVie employees and may own AbbVie stock. AbbVie sponsored and funded the study; contributed to the design; participated in the collection, analysis, and interpretation of data, and in writing, reviewing, and approval of the final abstract.