(340e) Decoupling Temperature and the Kinetics of Dye Conversion Via Scalable Nano-Encapsulation in a Thermal-Responsive Media
- Conference: AIChE Annual Meeting
- Year: 2019
- Proceeding: 2019 AIChE Annual Meeting
- Group: Pharmaceutical Discovery, Development and Manufacturing Forum
- Time: Tuesday, November 12, 2019 - 1:54pm-2:15pm
We seek to overcome this disadvantage by decoupling the kinetics of dye conversion from temperature through the implementation of a wax matrix surrounding dye nanocapsules. The wax matrix serves as a barrier which melts and exposes dye-encapsulated nanoparticles at a specific melting temperature, commensurate with that of the treatment process. To form dye nanocapsules directly in wax, the versatility of flash nanoprecipitation (FNP), a scalable nanoparticle fabrication technique, is expanded. In this work, an organic solution of dye and polymeric stabilizer is impinged against a molten wax to create turbulent mixing, yielding the super-saturation, precipitation, and subsequent two-level encapsulation of the dye. Characterization of the resultant nanoparticle-imbued waxes is presented as well as the response of encapsulated dye to treatments at temperatures above and below the melting point of various wax matrices. As a result, the ability of these novel materials to thermally trigger exposure and initiate the kinetic response of the dye is demonstrated. Nanoparticle-imbued waxes are shown to be amenable to further post-processing including emulsification, spray prilling, and printing.