(335b) A Comprehensive Study and Comparison of Four Types of Zwitterionic Hydrogels

Authors: 
Zhao, W., Tianjin University
Zhang, L., Tianjin University
Zwitterionic materials have been attracting significant attentions due to their excellent non-fouling and biocompatible properties, thus have been widely used in many biomedical applications such as wound dressings, biosensor devices, DNA vaccine delivery, surface modification of hemoadsorbent and marine coatings, etc. Zwitterionic moieties mainly consist of three major types: carboxybetaine (CB), sulfobetaine (SB), and phosphorylcholine (PC). Accordingly, the most commonly used zwitterionic monomers include carboxybetaine methacrylate (CBMA), carboxybetaine acrylamide (CBAA), sulfobetaine methacrylate (SBMA) and 2-methacryloyloxyethyl phosphorylcholine (MPC). However, differences among different types of zwitterionic materials have rarely been investigated and compared. In our work, four types of zwitterionic monomers were systematically studied and compared by testing the properties of the hydrogels. Their hydration, diffusion coefficient of water and mechanical properties were evaluated and analyzed. It was found that poly(carboxybetaine methacrylate) (PCBMA) hydrogel possessed the strongest compressive modulus, while poly(carboxybetaine acrylamide) (PCBAA) hydrogel showed the highest diffusion coefficient of water and highest hydration of water. Compared with other hydrogels, the mesh size of poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) hydrogel was the largest. Furthermore, poly(sulfobetaine methacrylate) (PSBMA) hydrogel with disulfide-crosslinker degraded faster than the others. Findings in our work provided insights and guidance for the selection of different zwitterionic polymers to suit different applications.
Topics: