(322g) Risk Assessment of Encrustation in Continuous Pharmaceutical Crystallization Process – a Case Study
AIChE Annual Meeting
Tuesday, November 12, 2019 - 2:36pm to 2:57pm
Encrustation is a risk factor that can cause product and process failure in continuous crystallization processes. Various risk mitigation strategies proposed in the literature, such as coating of crystallizer walls, use of additives to control encrustation kinetics, and periodic steady state operation show promising results in delaying or preventing encrustation.1-3 Due to increased interest in the use of continuous crystallization in industrial applications, it is important to understand this risk factor further. Recent developments on dynamic models, mechanisms and risk factors of encrustation in continuous crystallization processes will be discussed. Methodologies for detection, mitigation, or control of encrustation will be evaluated. Cooling crystallization of carbamazepine will be used as a case study to evaluate detection methodologies (visual, process analytical technology, etc.). Various design and control strategies to mitigate the encrustation risk are also proposed. Appropriate control strategies should be implemented during continuous crystallization to avoid the impact of encrustation on drug substance quality.
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