(322e) Multistage, Multi-Zones Antisolvent-Cooling Crystallisation of a Proprietary API: Comparison of Two Continuous Crystalliser
AIChE Annual Meeting
Tuesday, November 12, 2019 - 1:54pm to 2:15pm
At matched residence times for the two crystallisers, the particle size distribution obtained from the COBC was bigger having enhanced flow properties, less agglomeration propensity, higher yield and lower surface area compared to MSMPR. In addition, slightly reduced impurity rejection was observed in the COBC; meanwhile, the MSMPR resulted in lesser yield but higher impurity rejection. In terms of platform operations, more interventions were required to keep the COBC running with significant impact on process steady-state and potential shutdown. Fouling and encrustation were observed in both systems but could be reduced if processing conditions are optimised for COBC. In conclusion, the COBC which was primarily built for flexibility and relatively new in terms of applications resulted in better crystal attributes and higher yield compared to the MSMPR platform which is more established in terms of existing knowledge and operations, and more plant-ready. Optimisation of the process conditions in the COBC is strongly encouraged coupled with the redesign of the seed transfer line to prevent blockages.