(289g) Structural Guides: Influence of High Molecular Weight Polymer Additives on Low Molecular Weight Gels Towards Solid-State, Composites

Inspired by the responsive behavior of the fibrous, extracellular matrix architecture, we are interested in the design of dynamic, low molecular weight gel (LMWG) assemblies that utilize high molecular weight polymers as reinforcing additives. Guiding principles of the structural interplay dictated by component interactions, polymer chain conformation, and concentration were revealed. Depending on the conformation of the high molecular weight polymer in the gelation solvent and polymer-gel interactions, either transient or isolated, branched fiber networks developed, strongly influencing gel dissociation temperatures, and rheological response.

Our ultimate goal is the design of reconfigurable and responsive composites derived from LMWG fiber assemblies, transitioning from gel-state fundamentals to solid-state composites. Knowledge of the interplay between conformation of the polymer additive, non-covalent interactions and LMWG fiber structure in the gel state translated to a fundamental understanding of disassembly and assembly within the solid-state, gel composite analogs. Insight into restrictions on chain mobility, and decoupled gel network and matrix stability are highlighted, moving closer to the realization of solid-state switchability. New thrust areas in light guide assemblies, and therapeutic immobilization and tailored release are envisioned utilizing these polymer-gel systems.