(264c) Tailoring the Bioactivity of Flame-Made Nanoparticles for Surgical Applications | AIChE

(264c) Tailoring the Bioactivity of Flame-Made Nanoparticles for Surgical Applications

Authors 

Starsich, F., ETH Zurich
Schlegel, A., Queen Elizabeth University Hospital Birmingham
Pratsinis, S. E., ETH Zurich

Poorly healing injuries, especially after surgeries, pose
complex problems to surgeons
. Current wound management
solutions have several drawbacks including poor soft tissue adhesion and low
bioactivity.1 In this work, we show
the potential application of flame-made bioactive nanoparticle-based tissue
adhesives for a variety of wound healing applications.

In a first step, silica, iron oxide, ceria, borate glass,
and bioglass nanoparticles were produced by scalable liquid-feed
flame spray pyrolysis and their hemostatic
properties, and adhesion to soft tissue were assessed.2 The bioactivity of
the nanoparticles was then further tailored by creating hybrid and doped
versions by the same synthesis method featuring additional clinically relevant
properties including antimicrobial, angiogenic, and
antioxidant activities.3

Bioglass-based nanoparticles show exceptionally strong
adhesive properties and hemostatic activity. Bioglass-ceria hybrid nanoparticles produced in a two-spray
setup show unify the strong soft tissue adhesion of bioglass
with the antioxidant and cytoprotective activities of
ceria. The angiogenic and adhesive features of bioglass combined with the anti-inflammatory and
antioxidant properties of ceria make for a promising and comprehensive wound
management solution. In a first in vivo study4, the bioglass-ceria hybrid
nanoparticles significantly improved skin graft survival by improving revascularization.

In
summary, we will present how the rational engineering of flame-made metal-oxide
nanoparticles gives access to highly effective wound-care solutions.

(1)    Dhivya, S.; Padma, V. V.; Santhini,
E. Wound Dressings – a Review. Biomedicine (Taipei) 2015, 5
(4). https://doi.org/10.7603/s40681-015-0022-9.

(2)    Matter,
M. T.; Starsich, F.; Galli, M.; Hilber, M.; Schlegel, A. A.; Bertazzo, S.; Pratsinis, S. E.; Herrmann, I. K. Developing
a Tissue Glue by Engineering the Adhesive and Hemostatic
Properties of Metal Oxide Nanoparticles. Nanoscale 2017, 9
(24), 8418–8426. https://doi.org/10.1039/C7NR01176H.

(3)    Matter,
M. T.; Furer, L. A.; Starsich, F. H. L.; Fortunato, G.; Pratsinis, S. E.;
Herrmann, I. K. Engineering the Bioactivity of Flame-Made Ceria and Ceria/Bioglass Hybrid Nanoparticles. ACS Applied Materials
& Interfaces
2018. https://doi.org/10.1021/acsami.8b18778.

(4)    Lese,
I.; Graf, D. A.; Tsai, C.; Taddeo, A.; Matter, M. T.; Constantinescu, M. A.;
Herrmann, I. K.; Olariu, R. Bioactive Nanoparticle-Based Formulations Increase
Survival Area of Perforator Flaps in a Rat Model. PLOS ONE 2018, 13
(11), e0207802. https://doi.org/10.1371/journal.pone.0207802.