(221l) Calibration of Chromatographic Effects in Capillary Flow

The development and use of combinatorial experimental methods and informatics-based data analyses have revolutionized the drug discovery and pharmaceutical industries¹. These new experimental approaches and practices have dramatically reduced the time required to bring new drugs and therapies to market. In addition to large and multivariate combinatorial-based experimental designs and informatics-based data mining and management, the development and use of new automated liquid handling and dispensing technologies have played an essential role in reducing the time required to complete large-scale and complex experimental assays and studies. More recently, combinatorial experimental techniques have been successfully adapted and extended in other technology domains most notably in the discovery, synthesis and optimization of new materials, compounds and composites². In this presentation, discussion of how combinatorial methods and a new high-throughput digital titration technology are being applied to the development, characterization and optimization of new 3D printing materials and processes will be described.

1. Posner, B. A. High-throughput screening-driven lead discovery: meeting the challenges of finding new therapeutics. Curr. Opin. Drug Discov. Devel. 8, 487–494 (2005).
2. Amis, E., Xiang, X.-D. & Zhao, J.-C. Combinatorial Materials Science: What’s New Since Edison? MRS Bull. 27, (2002).