(187i) An Advanced 3D Computational Model for Designing Next Generation Drug Carriers

Multi-compartment microcapsules are promising transport vehicles for next generation
of smart drug delivery carriers. Several diseases and disorders such as HIV require simultaneous
delivery of multiple active pharmaceutical ingredients. In such cases, the active ingredients must
be delivered to the targeted area of the human body and released simultaneously. Thus, multiple
smaller microcapsules including different active ingredients are encapsulated inside a mother
microcapsule. The present work utilizes a state-of-the-art advanced computational methodology
(membrane spectral boundary element method) that accurately predicts multi-compartment
microcapsules deformation and motion in vascular channels. The developed three-dimensional
model provides an enhanced understanding on the complex hydrodynamic behavior of these drug
carriers. The interfacial interactions of inner capsules with the mother capsule in confined
geometries are studied, and insights for optimization and advance manufacturing of next
generation of smart drug carriers are presented.