(182ad) Fabrication of Porous Polysaccharide Based Biomaterials with Active Therapeutic Delivery Capability Using Supercritical CO2
AIChE Annual Meeting
Monday, November 11, 2019 - 3:30pm to 5:00pm
Several scaffolds in which sensitive bioactive molecules (proteins, natural extracts, and antibacterial drugs) are incorporated will be evaluated for their ability as controlled-release and antimicrobial carriers. In order to control protein/drug release patterns, during the design of multifunctional scaffolds, the effect of processing parameters on scaffolds microstructure (porosity) and on the resulting protein/drug release profile, stability, biodegradation behavior, as well as the scaffoldsâ mechanical properties will be investigated to support the proliferation of cells and tissue growth. Scaffolds incorporated with antimicrobial agents will be challenged against Staphylococcus aureus (Gram-positive bacteria), the prevailing virulent bacteria for early infections, and Escherichia coli (gram-negative bacteria), a common bacterial source of intra-hospital infections. Biocompatibility of scaffolds obtained with open pore structure will confirmed with live/dead assay, after sufficient time for cell culture.