(182ab) Drug Delivery System for Platinum Nanoparticles
AIChE Annual Meeting
Monday, November 11, 2019 - 3:30pm to 5:00pm
Cisplatin (cis-diamminedicholoroplatinum(II)) is one of the more commonly used platinum based agents. It is used in almost 50% of tumor therapies as a chemotherapy drug. But, cisplatin has several limitations and is plagued with side effects like nephrotoxicity (toxicity in the kidneys), cardiotoxicity (damage to the heart), hepatotoxicity (toxicity in the liver), and neurotoxicity (alteration of the normal activity of the nervous system). Due to the many side effects of cisplatin, less toxic platinum nanoparticles (PtNPs) are an attractive solution to overcome this toxicity problem. Nanomedicine offers the option to act selectively against cancer and enhance the effectiveness of other therapies. The activity of nanoparticles is based on their small size and high surface area; these properties allow them to penetrate biofilms as well as influence intracellular mechanisms. Recent studies indicate that platinum nanoparticles can be used as a therapy for cancer showing a limited toxicity to healthy cells. The activity of platinum nanoparticles can be related to the release of Pt2+ ions, which damage DNA via double-strand breaks causing growth arrest and apoptosis. In this work, platinum nanoparticles were synthesized adapting the work from Shim et al., to produce particles of 45nm. Triple negative breast cancer and fibroblast cells were treated with the PtNPs, showing a remarkable anticancer activity with a limited toxicity to healthy cells.
Moreover, to enhance the circulation of the particles and accumulation at the tumor site a delivery system is preferred. Poly(lactide-co-glycolide) (PLGA) particles where synthesized as a delivery system for PtNPs. PLGA is a copolymer of poly(lactic acid) (PLA) and poly(glycolic acid) (PGA), those two monomers are metabolized by the body, making PLGA toxicity minimal. In this work, the encapsulation of PtNPs within PLGA particles was performed by three different methodologies: nanoemulsion, electrospinning and nanoprecipitation. By using TEM, the successful encapsulation of PtNPs inside PLGA particles of 150nm was confirmed.