(181ac) Aqueous Media Resistant PVA/HPMC Nanofibers By Electrospinning Technique for Drug Delivery System
With this aim, a novel layered material combining PVA and HPMC containing amoxicillin has been prepared. To optimize its later use in implants and oral surgery, it was opted for its preparation in the form of nanofiber using the electrospinning technique. In order to confer its stability under aqueous media, it has been evaluated a cross-linking method using glutaraldehyde (GA).
Layered samples (not cross-linked and cross-linked) were prepared and characterized, as well as the pure materials (PVA, HPMC, GA and amoxicillin) for their comparation. Scanning electron microscope (SEM) images confirm the stability and the morphology of the nanofibers once the layered sample, after cross-linking process, is immersed in an aqueous solution. However, the layered sample, which was not cross-lined, loses its nanofiber morphology, becomes a gelatinous material and finally, dissolved.
Furthermore, Fourier-transform infrared spectroscopy (FTIR) and thermal-gravimetry analyses (TGA) show the contribution of the pure materials in the layered sample (cross-linked). For the release tests, a buffer solution simulating saliva (with a pH of 6.8 and at 37 °C) is used. The results show a controlled release using the layered sample (cross-linked).
In conclusion, the layered sample prepared and treated by a cross-linking process, shows successful results, remaining its nanofiber morphology and being it a stable material for its purpose.