(175be) Electrotherapeutic Aided Wound Healing: A Fundamental Study on the Effects of Electromagnetic Fields on the Diffusion of Thrombin through Porous Gel Media

Among the many advances in the biomedical sciences, the bio-mathematical foundation of homeostatic wound healing has been underserved in the scientific community. New approaches to wound healing can improve outcome for emergent response, high risk, and surgical patients by reducing wound exposure to nonsterile environment. With the previous efforts in wound healing done by at Tennessee Technological University by Dr. Stephanie Jorgenson in conjunction with advances done in electrotherapeutic drug delivery by Esparza and Oyanader¹ can provide a novel pathway for advances in the medical field. In the approach taken by Esparza, an appropriate use of the Robin boundary condition towards the identified system allowed for the natural minimum concentration to be identified. For the study, the molar species continuity equation with the included electrophysical variable has been used as the governing fundamental equation to be solved analytically. This fundamental study will review the effects of electromagnetic forces on the diffusion of thrombin to induce the conversion of fibrinogen to fibrin through different values of porosity and tortuosity in a porous gel media. In conclusion, the results will provide a mathematical foundation for electro-aided wound healing as a possible treatment protocol to improve patient outcome.