(174q) Amino Acid Coated Coated Gd2O3 Nanoparticles As a Potential T2 MRI-CT Dual Contrast Agents
AIChE Annual Meeting
2019
2019 AIChE Annual Meeting
Poster Sessions
General Poster Session I
Monday, November 11, 2019 - 3:30pm to 5:00pm
Gadolinium (Gd) is a unique and powerful element in chemistry and biomedicine
which can be applied simultaneously to magnetic resonance imaging (MRI) and sensor. We report a facile method to synthesize Gd2O3 nanoparticles for use as contrast agents in MRI. The nanoparticles were coated with ligand. The bonding status of ligand coated Gd2O3 nanoparticles were confirmed by FT-IR and TGA. High voltage electron microscope (HVEM) shows that diacid coated (DA) coated Gd2O3 nanoparticles were spherical in shape with an average diameter 3 mM. In addition, the bio-compatibility of the nanoparticles were measured by cytotoxicity tests by using human prostate cancer (DU145) and normal mouse hepatocyte (NCTC1469) cell lines which indicated that DA coated Gd2O3 nanoparticles are not toxic up to 200 mM, making them a promising candidate for bio-medical applications. The high relaxivities provide an opportunity to conduct perfusion MRI experiments with significantly lower concentrations than those needed for current commercial agents.
which can be applied simultaneously to magnetic resonance imaging (MRI) and sensor. We report a facile method to synthesize Gd2O3 nanoparticles for use as contrast agents in MRI. The nanoparticles were coated with ligand. The bonding status of ligand coated Gd2O3 nanoparticles were confirmed by FT-IR and TGA. High voltage electron microscope (HVEM) shows that diacid coated (DA) coated Gd2O3 nanoparticles were spherical in shape with an average diameter 3 mM. In addition, the bio-compatibility of the nanoparticles were measured by cytotoxicity tests by using human prostate cancer (DU145) and normal mouse hepatocyte (NCTC1469) cell lines which indicated that DA coated Gd2O3 nanoparticles are not toxic up to 200 mM, making them a promising candidate for bio-medical applications. The high relaxivities provide an opportunity to conduct perfusion MRI experiments with significantly lower concentrations than those needed for current commercial agents.