(174c) The Important Role That Size Plays into Polydopamine Nanoparticles’ Antiproliferative Activity | AIChE

(174c) The Important Role That Size Plays into Polydopamine Nanoparticles’ Antiproliferative Activity

Authors 

Nieto Jiménez, C. - Presenter, University of Salamanca
Martín del Valle, E. M., University of Salamanca
Vega, M., University of Salamanca
Galán, M. A., University of Salamanca
Marcelo, G., University of Salamanca
Enrique, J., University of Salamanca
In recent years, the use of polydopamine as a nanomaterial for devising novel diagnosis and therapeutic systems has acquired great relevance [1,2]. This fact has been favored because the biocompatibility, coating ability and chemical versatility of this synthetic melanin analogue had been demonstrated and, moreover, because its ability to chelate diverse metallic cations was already known [3, 4].

In previous studies, polydopamine nanoparticles were synthetized and their antiproliferative effect, as well as their interaction with different metallic cations, were analyzed with a couple of cancer cell lines [1, 2]. In such works, it was proven that both, non-loaded and metal-loaded polydopamine nanoparticles, could have useful properties for nanomedicine research. As consequence, the main goal of this work has been to elucidate how the size of these nanoparticles could affect to their already shown cancer antiproliferative activity and how it varies depending on the type of cancer.

To achieve this objective, polydopamine nanoparticles with three different diameters (50, 130 and 480 nm) have been synthetized. On one hand, the effect of the two smaller ones over the viability of different cancer (BT474, HEPG2, HTC116 and H460) and healthy (HS5) human cell lines has been analyzed. On the other hand, the antiproliferative effect of the three types of polydopamine nanoparticles in the BT474 cell line was determined. As result, it has been proven that the smaller the size of the polydopamine nanoparticles, the greater antiproliferative effect they present, being such effect more notable in the cellular lines that have a higher intracellular iron concentration.

References

[1] M.A. Vega, C. Nieto, G. Marcelo, E.M. Martín del Valle. Colloids Surf. B Biointerfaces, 2018, 167, 284-290.

[2] Y. Cheng, S. Zhang, N. Kang, J. Huang, X. Lv, K. Wen, S. Ye, Z. Chen, X. Zhou, L. Ren. ACS Appl. Mater. Interfaces, 2017, 9(22), 19296-19306.

[3] C. Nieto, M.A. Vega, G. Marcelo, E.M. Martín del Valle. RSC Adv., 2018, 8, 36201-36208.

[4] D.R. Dreyer, D.J. Miller, B.D. Freeman, D.R. Paul, C.W. Bielawski. Langmuir, 2012, 28, 6428-6435.