- Conference: AIChE Annual Meeting
- Year: 2018
- Proceeding: 2018 AIChE Annual Meeting
- Group: Pharmaceutical Discovery, Development and Manufacturing Forum
- Time: Wednesday, October 31, 2018 - 8:00am-8:10am
As the reaction proceeds, coagulum is formed which can coat the impellers and vessel walls or form large masses which can damage the agitator if they impact the blades or shaft. The formation of coagulum can be minimized by using an impeller that generates a high flow but, at the same time, it must provide sufficient shear to generate the desired monomer droplets.
This presentation will compare impeller properties and review how they can be selected to achieve the correct balance to flow and shear. A case study on retrofitting in a suspension polymerization reactor will be presented.