(94f) Dense Packing of Cell Monolayers: Jamming of Deformable Polygons
AIChE Annual Meeting
2018 AIChE Annual Meeting
Particle Technology Forum
Modeling of Particulate Systems
Monday, October 29, 2018 - 9:30am to 9:48am
Collective motion in dense packings of cells occurs in wound healing, embryonic development, and cancerous tumor growth. Most current computational models of dense cell packings either treat the system as collections of spherical particles or assume that the system is confluent, with no extracellular space. We have developed a new model for dense cell packings in two and three spatial dimensions, where the cells are modeled as deformable particles that have a preferred area and perimeter in 2D and a preferred area and volume in 3D. We measure the packing fraction, Ïj at jamming onset as a function of the asphericity, Î±, which is the ratio of the perimeter square to the area of the particle i. We find that the jammed packing fraction increases monotonically with Î± and that the system becomes confluent with Ïj = 1 for Î± > 1.16. Using surface Voronoi analysis, we show that this value for Î± corresponds to the case when the cells completely fill their Voronoi-tesselated regions. We also demonstrate that the free area per cell obeys a k-gamma distribution, which has been found for jammed packings of non-deformable particles. Finally, we will describe results from our model concerning the mobility of deformable particles subjected to applied forces, as well as diffusion of deformable particles subjected to active forces to discuss the effect of geometry in active jamming of deformable particles.