(744b) Catalytic Amino Acid Production from Biomass
AIChE Annual Meeting
2018 AIChE Annual Meeting
Catalysis and Reaction Engineering Division
Catalytic Upgrading of Alternative Carbon Feedstocks
Friday, November 2, 2018 - 12:48pm to 1:06pm
Amino acids are the building blocks for protein biosynthesis and find use in myriad industrial applications including use in food for humans, in animal feed, and as precursors for bio-based plastics, among others. However, the development of efficient and general chemical methods to convert abundant and renewable feedstocks into amino acids has been largely unsuccessful to date. To that end, here we report a heterogeneous catalyst that directly transforms lignocellulosic biomass-derived Î±-hydroxyl acids into Î±-amino acids, including alanine, leucine, valine, aspartic acid, tyrosine, and phenylalanine in high yields. The reaction follows a dehydrogenation-reductive amination pathway, with dehydrogenation as the rate-determining step. Ruthenium nanoparticles supported on carbon nanotubes (Ru/CNT) exhibit exceptional efficiency compared to catalysts based on other metals, due to the unique, reversible enhancement effect of NH3 on Ru in dehydrogenation. Based on the new catalytic system, a two-step chemical process was designed to convert glucose into alanine in 43% yield, comparable with the well-established microbial cultivation process, and therefore, the present strategy enables a new route for the production of amino acids from renewable feedstocks. Moreover, a conceptual process design employing membrane distillation to facilitate product purification is proposed and validated. Overall, this study offers a rapid and potentially more efficient chemical method to produce amino acids from woody biomass components.