(719f) Predicting Shear, Energy Dissipation, and Blending in Bioreactors for Mammalian Cells
AIChE Annual Meeting
Thursday, November 1, 2018 - 5:10pm to 5:35pm
In this work, we discuss how large eddy simulation can be used to perform time-accurate, three-dimensional numerical experiments of agitated bioreactors. After this theoretical overview, we use this approach to predict the time-evolution of the shear and energy dissipation fields across the fluid domain. Next, we show how this time-accurate model can be used to perform real-time blending and recirculation experiments on modest computational resources. We conclude showing how cell trajectories can be integrated in tandem with the fluid motion to predict the precise hydrodynamic environments experienced by many cells as they move about a tank.